VSClust: Variance-sensitive fuzzy clustering

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Last accessed Apr 06, 2025
Author Veit Schwämmle Associate Professor for Computational Proteomics and Bioinformatics, University of Southern Denmark

About the app

VSClust is a powerful app that employs a new method to apply fuzzy c-means clustering to data sets that exhibit non-constant variance of their features. The individual variation is incorporated into the estimation of the fuzzifier (parameter m). For details see - Veit Schwämmle, Ole N Jensen; VSClust: Feature-based variance-sensitive clustering of omics data, Bioinformatics, 2018, bty224, https://doi.org/10.1093/bioinformatics/bty224 The algorithm for the estimation of the parameters fuzzifier and cluster numbers is furthermore based on - Schwämmle, V. and Jensen, O. N. "A simple and fast method to determine the parameters for fuzzy c-means cluster analysis". Bioinformatics, 2010, 26, 2841-2848. Note that this method reveals its power for 8 or more different conditions (dimensions). Lower numbers yields results nearly identical to standard fuzzy c-means clustering.

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